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R based review of regression
more regression notes
Problems with stepwise regression
GOSSET = minimum prediction experimental variance (assumes quadratic model can be as complex as desired)
INFAC is a similar software package, but is not open sourced or maintained. INFAC = Incomplete Factorial Experiment Design. It seems similar to a linear model used in GOSSET.
Model Optimizationuses the coefficients and parameters from your experiments to estimate what the most likely model is. This is done using the Akaike information criterion stepwise regression. This is a maximum information algorithm to estimate what the best model is given experimental results. A Monte Carlo search is then employed to find the maximum yield using the model.